1. 教育经历

2004/09-2008/07，中山大学生命科学学院，理学学士

2010/09-2015/12，香港大学化学系，博士

2. 科研与工作经历

2016/01-2018/12，香港大学化学系，博士后

2019/02-2020/08，德国马普感染生物学研究所，博士后

2020/10-至今，中山大学附属第五医院分子影像中心，副研究员

我们课题组研究病原细菌与宿主的互作，近期特别关注金属离子调控机体抗感染固有免疫信号的机理。研究兴趣主要包括：

研究细菌病原体如何操控宿主细胞固有免疫信号通路；

探索在感染过程中机体如何利用金属离子调节免疫信号。

我们希望揭示金属介导的免疫信号传导（即金属免疫学）的机制，并利用这些知识开发更有效的疾病治疗方法（感染疾病、自身免疫疾病、肿瘤等）。

中山大学“百人计划”科研项目, 2020-2023,主持

近期代表性文章

1. Jing Lu#, Xue Liu#, Xinghua Li, Hongyan Li, Liwa Shi, Xin Xia, Bai-liang He, Thomas F. Meyer, Xiaofeng Li*, Hongzhe Sun*, Xinming Yang*, Copper regulates the host innate immune response against bacterial infection via activation of ALPK1 kinase. Proceedings of the National Academy of Sciences of the United States of America. 121(4):e2311630121(2024)

2. H Wang, X Yang^#, M Wang, M Hu, X Xu, A Yan, Q Hao, H Li, H Sun, Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chemical Science. 11 (43), 11714-11719 (2020)

3. H Wang, Y Wang^#, X Yang, H Li, J Wang, H Sun, Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach. M Koohi-Moghadam, Nature Machine Intelligence 1 (12), 561-567 (2019)

4. H Wang, A Yan, Z Liu, X Yang, Z Xu, Y Wang, R Wang, M Koohi-Moghadam, L Hu, W Xia, H Tang, Y Wang, H Li, H Sun, Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli. PLOS Biology17 (6), e3000292 (2019)

5. H Wang, M Wang, X Yang^#, X Xu, Q Hao, A Yan, M Hu, R Lobinski, H Li, H Sun, Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli. Chemical science10 (30), 7193-7199 (2019)

6. X Yang^#, M Koohi-Moghadam, R Wang, YY Chang, PCY Woo, J Wang, H Li, H Sun, Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. PLOS Biology 16 (1), e2003887 (2018)

7. X Yang^#, H Li, TP Lai, H Sun, UreE-UreG complex facilitates nickel transfer and preactivates GTPase of UreG in Helicobacter pylori. Journal of Biological Chemistry 290 (20), 12474-12485 (2015)

8. X Yang^#, H Li, T Cheng, W Xia, YT Lai, H Sun, Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori. Metallomics 6 (9), 1731-1736 (2014)

9. W Xia, H Li, X Yang^#, KB Wong, H Sun, Metallo-GTPase HypB from Helicobacter pylori and its interaction with nickel chaperone protein HypA. Journal of Biological Chemistry 287 (9), 6753-6763 (2012)