何欢欢，中山大学附属第五医院研究员，博士生导师，国家优青。2013年于加州大学洛杉矶分校获得博士学位，之后在斯坦福大学及俄勒冈健康与科学大学从事博士后训练。2017年9月以中山大学“百人计划”中青年杰出人才引进，并获得“广东省杰出青年医学人才”、“珠海市高层次人才（第三类）”和“中山大学优秀博士生导师”等称号。主要从事肿瘤免疫和血管相关疾病的研究，工作既注重发展基础理论，又紧密联系临床应用。任广东省转化医学学会心血管分会副主委，广东省精准医学应用学会老年慢病分会副主委，广东省医学会医学遗传分会委员，珠海市科学技术协会第七次代表大会代表，广东欧美同学会理事会理事, Journal of Leukocyte Biology 副主编，同时还是美国癌症研究协会（AACR）和美国女性科学者协会（Associationfor Women in Science）会员。

1.肿瘤微环境的单细胞转录组学研究；

2.脉管发育及相关疾病的多组学研究；

3.多种妇科疾病的致病机制探讨。

在研科研项目：

1. 国家自然科学基金优秀青年科学基金项目， 2024/01-2026/12，主持

2. 国家自然科学基金重大研究计划培育项目，2022/01-2024/12，主持

已结题科研项目：

1. 广东省科技计划项目，2020/01-2021/12，主持

2. 国家自然科学基金面上项目，2019/01-2022/12，主持

3. 国家自然科学基金应急项目，2018/01-2018/12，主持

近期代表性文章

1. Haopei Zhang^#, Qiuyue Chen^#,Qianqian Zhang, Hairun Gan, Hanjie Li, Shoudeng Chen*, Hong Shan*, PengfeiPang*, Huanhuan He*,DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis invascular malformations, InternationalJournal of Biological Sciences., 2023; 19(13): 4123-4138

2. YuJiao Gong^#, Yan Liang^#, Jie Liu^#,Jiaxing Wei^#, Shushan Zhang, Fangbin Chen, Qianqian Zhang, LijieWang, Huimin Lan, Wei Ge, Shuai Li*, Li Wang*, Hong Shan*, Huanhuan He*, DDX24is essential for cell cycle regulation in vascular smooth muscle cells duringvascular development via binding to FANCA mRNA, Arteriosclerosis Thrombosis andVascular Biology., 2023, 43(9):1653-1667

3. Tianze Liu^#, Hairun Gan^#, Simeng He^#,Jia Deng^#, Xinyan Hu^#, Luting Li, Cai Li, Jianzhong He,Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen,Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jianhua Yang, DongmingKuang*,  Pengfei Pang*, HuanhuanHe*, Hong Shan*, RNA helicase DDX24 stabilizes LAMB1 to promotehepatocellular carcinoma progression, Cancer Research., 2022, 82(17):3074-3087

4. Famin Zeng^#, Yingwen Li^#, Zhaohua Deng^#,Jianzhong He^#, Wei Li, Lijie Wang, Ting Lyu, Zhanyu Li, ChaomingMei, Meilin Yang, Yingying Dong, Guanmin Jiang, Xiaofeng Li, Xi Huang, FeiXiao*, Ye Liu*, Hong Shan*, HuanhuanHe*, SARS-CoV-2 spike spurs intestinal inflammation via VEGFproduction in enterocytes, EMBOMolecular Medicine., 2022, 14(5):e14844

5. Cuizan Cai, Xuxu Zhuang, Qi Zhu, Mingyue Wu, Huanxing Su,Xiaojin Wang, Iyaswamy Ashok, Zhenyu Yue, Qian Wang, Bin Zhang, Yu Xue,Jieqiong Tan, Min Li, HuanhuanHe*, Jiahong Lu*, Enhancing autophagy maturation withCCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimerdisease models, Theranostics.,2022, 12(4): 1738–1755

6. Shibo Zhang^#,Bingfan Xie^#, Lijie Wang^#, Hua Yang^#, HaopeiZhang, Yuming Chen, Feng Wang, Changqing Liu*, Huanhuan He*,Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictatesascites development in ovarian cancer, The Journal of Clinical Investigation.,2021, 131(3):e140315

7. Yuan Wei, ChunxiangHuang, Xiao Xiao, Dongping Chen, Hong Shan*, Huanhuan He*,Dongming Kuang*, B cell heterogeneity, plasticity, and functional diversity incancer microenvironments, Oncogene.,2021, 40(29):4737-4745

8. Pengfei Pang^#,Xiaojun Hu^#, Bin Zhou^#, Junjie Mao^#, Yu Liang,Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian,Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu*, Yiming Wang*, Huanhuan He*, HongShan*, DDX24 mutations associated with malformations of major vessels to theviscera, Hepatology.,2019, 69(2):803-816

9. Huanhuan He^#, Julia J Mack, Esra Guc, Carmen M Warren, Mario LeonardoSquadrito, Witold W Kilarski, Caroline Baer, Ryan D Freshman, Austin IMcDonald, Safiyyah Ziyad, Melody A Swartz, Michele De Palma, M LuisaIruela-Arispe*, Perivascular macrophages limit permeability, Arterioscler Thromb Vasc Biol.,2016, 36(11): 2203-2212

2024年：国家优青

2023年：华夏医学科技奖“三等奖”

2021年：中山大学优秀博士生导师

2020年：珠海市高层次人才（第三类）

2019年：广东省杰出青年医学人才

2017年：中山大学“百人计划”中青年杰出人才